2025
S. Saxena, S. Liebscher, Boosting the X factor: Increasing XBP1s-mediated ER stress signaling protects motor neurons in ALS/FTD. Molecular Therapy 33, 844 (2025).
A. Rezaei, V. Kocsis-Jutka, Z. I. Gunes, Q. Zeng, G. Kislinger, F. Bauernschmitt, H. B. Isilgan, L. R. Parisi, T. Kaya, S. Franzenburg, J. Koppenbrink, J. Knogler, T. Arzberger, D. Farny, B. Nuscher, E. Katona, A. Dhingra, C. Yang, G. Gouna, K. D. LaClair, A. Janjic, W. Enard, Q. Zhou, N. Hagan, D. Ofengeim, E. Beltran, O. Gokce, M. Simons, S. Liebscher, D. Edbauer, Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice. Nat Commun 16, 3442 (2025).
2024
J. Scekic-Zahirovic, C. Benetton, A. Brunet, X. Ye, E. Logunov, V. Douchamps, S. Megat, V. Andry, V. W. Y. Kan, G. Stuart-Lopez, J. Gilet, S. J. Guillot, S. Dirrig-Grosch, C. Gorin, M. Trombini, S. Dieterle, J. Sinniger, M. Fischer, F. Rene, Z. Gunes, P. Kessler, L. Dupuis, P. F. Pradat, Y. Goumon, R. Goutagny, V. Marchand-Pauvert#, S. Liebscher#, C. Rouaux#, Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Science Translational Medicine 16, eadg3665 (2024).
# shared senior position
C. Douthwaite, C. Tietje, X. Ye, S. Liebscher, Probing cerebellar circuit dysfunction in rodent models of spinocerebellar ataxia by means of in vivo two-photon calcium imaging. STAR protocols 5, 102911 (2024).
C. A. Hurler, S. Liebscher, T. Arzberger, S. Jakel, Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin-embedded brain tissue. Brain Commun 6, fcae430 (2024).
2023
M. Ceanga, V. Rahmati, H. Haselmann, L. Schmidl, D. Hunter, A. K. Brauer, S. Liebscher, J. Kreye, H. Pruss, L. Groc, S. Hallermann, J. Dalmau, A. Ori, M. Heckmann, C. Geis, Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony. Cell Rep 42, 113166 (2023).
Z. I. Kolabas, L. B. Kuemmerle, R. Perneczky, B. Forstera, S. Ulukaya, M. Ali, S. Kapoor, L. M. Bartos, M. Buttner, O. S. Caliskan, Z. Rong, H. Mai, L. Hoher, D. Jeridi, M. Molbay, I. Khalin, I. K. Deligiannis, M. Negwer, K. Roberts, A. Simats, O. Carofiglio, M. I. Todorov, I. Horvath, F. Ozturk, S. Hummel, G. Biechele, A. Zatcepin, M. Unterrainer, J. Gnorich, J. Roodselaar, J. Shrouder, P. Khosravani, B. Tast, L. Richter, L. Diaz-Marugan, D. Kaltenecker, L. Lux, Y. Chen, S. Zhao, B. S. Rauchmann, M. Sterr, I. Kunze, K. Stanic, V. W. Y. Kan, S. Besson-Girard, S. Katzdobler, C. Palleis, J. Schadler, J. C. Paetzold, S. Liebscher, A. E. Hauser, O. Gokce, H. Lickert, H. Steinke, C. Benakis, C. Braun, C. P. Martinez-Jimenez, K. Buerger, N. L. Albert, G. Hoglinger, J. Levin, C. Haass, A. Kopczak, M. Dichgans, J. Havla, T. Kumpfel, M. Kerschensteiner, M. Schifferer, M. Simons, A. Liesz, N. Krahmer, O. A. Bayraktar, N. Franzmeier, N. Plesnila, S. Erener, V. G. Puelles, C. Delbridge, H. S. Bhatia, F. Hellal, M. Elsner, I. Bechmann, B. Ondruschka, M. Brendel, F. J. Theis, A. Erturk, Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell 186, 3706 (2023).
F. Pilotto, C. Douthwaite, R. Diab, X. Ye, Z. Al Qassab, C. Tietje, M. Mounassir, A. Odriozola, A. Thapa, R. A. M. Buijsen, S. Lagache, A. C. Uldry, M. Heller, S. Muller, W. M. C. van Roon-Mom, B. Zuber, S. Liebscher#, S. Saxena#, Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1. Neuron 111, 2523 (2023).
# shared senior position
2022
P. d’Errico, S. Ziegler-Waldkirch, V. Aires, P. Hoffmann, C. Mezo, D. Erny, L. S. Monasor, S. Liebscher, V. M. Ravi, K. Joseph, O. Schnell, K. Kierdorf, O. Staszewski, S. Tahirovic, M. Prinz, M. Meyer-Luehmann, Microglia contribute to the propagation of Abeta into unaffected brain tissue. Nature Neuroscience 25, 20 (2022).
A. Zambusi, K. T. Novoselc, S. Hutten, S. Kalpazidou, C. Koupourtidou, R. Schieweck, S. Aschenbroich, L. Silva, A. S. Yazgili, F. van Bebber, B. Schmid, G. Moller, C. Tritscher, C. Stigloher, C. Delbridge, S. Sirko, Z. I. Gunes, S. Liebscher, J. Schlegel, H. Aliee, F. Theis, S. Meiners, M. Kiebler, D. Dormann, J. Ninkovic, TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nature Neuroscience 25, 1608 (2022).
L. Empl, A. Chovsepian, M. Chahin, W. Y. V. Kan, J. Fourneau, V. Van Steenbergen, S. Weidinger, M. Marcantoni, A. Ghanem, P. Bradley, K. K. Conzelmann, R. Cai, A. Ghasemigharagoz, A. Erturk, I. Wagner, M. Kreutzfeldt, D. Merkler, S. Liebscher, F. M. Bareyre, Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury. Nat Commun 13, 2659 (2022).
J. Schneider, J. Weigel, M. T. Wittmann, P. Svehla, S. Ehrt, F. Zheng, T. Elmzzahi, J. Karpf, L. Paniagua-Herranz, O. Basak, A. Ekici, A. Reis, C. Alzheimer, O. F. Ortega de la, S. Liebscher, R. Beckervordersandforth, Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. EMBO J 41, e110409 (2022).
Z. I. K. Gunes, Vanessa W. Y. ; Jiang, Shenyi; Logunov, Evgeny; Ye, XiaoQian; Liebscher, Sabine, Cortical Hyperexcitability in the Driver’s Seat in ALS. Clinical and Translational Neuroscience 6, (2022).
2021
V. Korzhova, P. Marinković, J. R. Njavro, P. M. Goltstein, F. Sun, S. Tahirovic, J. Herms, S. Liebscher, Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice. Communications Biology 4, 1368 (2021).
S. Blumenstock, F. Sun, C. Klaus, P. Marinković, C. Sgobio, L. Paeger, S. Liebscher#, J. Herms#, Cortical circuit dysfunction in a mouse model of alpha-synucleinopathy in vivo. Brain Commun 3, fcab273 (2021). # shared senior position
J. Scekic-Zahirovic, I. Sanjuan-Ruiz, V. Kan, S. Megat, P. De Rossi, S. Dieterle, R. Cassel, M. Jamet, P. Kessler, D. Wiesner, L. Tzeplaeff, V. Demais, S. Sahadevan, K. M. Hembach, H. P. Muller, G. Picchiarelli, N. Mishra, S. Antonucci, S. Dirrig-Grosch, J. Kassubek, V. Rasche, A. Ludolph, A. L. Boutillier, F. Roselli, M. Polymenidou, C. Lagier-Tourenne, S. Liebscher#, L. Dupuis#, Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects. Nat Commun 12, 3028 (2021).
# shared senior position
H. Steffens, A. C. Mott, S. Li, W. Wegner, P. Svehla, V. W. Y. Kan, F. Wolf, S. Liebscher#, K. I. Willig#, Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity. Science Advances 7, (2021).
# shared senior position
< 2021
Z. I. Gunes, V. W. Y. Kan, X. Ye, S. Liebscher, Exciting Complexity: The Role of Motor Circuit Elements in ALS Pathophysiology. Frontiers in Neuroscience 14, 573 (2020).
S. Liebscher, G. B. Keller, P. M. Goltstein, T. Bonhoeffer, M. Hubener, Selective Persistence of Sensorimotor Mismatch Signals in Visual Cortex of Behaving Alzheimer’s Disease Mice. Current biology 26, 956 (2016).
S. Liebscher, R. M. Page, K. Kafer, E. Winkler, K. Quinn, E. Goldbach, E. F. Brigham, D. Quincy, G. S. Basi, D. B. Schenk, H. Steiner, T. Bonhoeffer, C. Haass, M. Meyer-Luehmann, M. Hubener, Chronic gamma-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Molecular Psychiatry 19, 937 (2014).
J. F. McCarter, S. Liebscher, T. Bachhuber, C. Abou-Ajram, M. Hubener, B. T. Hyman, C. Haass, M. Meyer-Luehmann, Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease. Acta Neuropathologica 126, 179 (2013).
S. Liebscher, M. Meyer-Luehmann, A Peephole into the Brain: Neuropathological Features of Alzheimer’s Disease Revealed by in vivo Two-Photon Imaging. Frontiers in Psychiatry 3, 26 (2012).
A. Capell, S. Liebscher, K. Fellerer, N. Brouwers, M. Willem, S. Lammich, I. Gijselinck, T. Bittner, A. M. Carlson, F. Sasse, B. Kunze, H. Steinmetz, R. Jansen, D. Dormann, K. Sleegers, M. Cruts, J. Herms, C. Van Broeckhoven, C. Haass, Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. J Neurosci 31, 1885 (2011).
H. Rebholz, A. Nishi, S. Liebscher, A. C. Nairn, M. Flajolet, P. Greengard, CK2 negatively regulates Galphas signaling. Proceedings of the National Academy of Sciences of the United States of America 106, 14096 (2009).
L. Gunther, S. Liebscher, M. Jahkel, J. Oehler, Effects of chronic citalopram treatment on 5-HT1A and 5-HT2A receptors in group- and isolation-housed mice. European Journal of Pharmacology 593, 49 (2008).